Zimmermann, Andreas Kainz, Katharina Hofer, Sebastian J. Bauer, Maria A. Schroeder, Sabrina Dengjel, Jörn Pietrocola, Federico Kepp, Oliver Ruckenstuhl, Christoph Eisenberg, Tobias Sigrist, Stephan J. Madeo, Frank Kroemer, Guido Carmona-Gutierrez, Didac 2019-06-05 GATA transcription factors (TFs) constitute a conserved family of zinc-finger TFs that fulfill diverse functions across eukaryotes. Accumulating evidence suggests that GATA TFs also play a role in lifespan regulation. In a recent study, we identified a natural polyphenol, 4,4’-dimethoxychalcone (DMC), that extends lifespan depending on reduced activity of distinct GATA TFs. Prolonged lifespan by DMC treatment depends on autophagy, a protective cellular self-cleansing mechanism. In yeast, DMC reduces the activity of the GATA TF Gln3 and, genetic deletion of Gln3 is sufficient to increase autophagy levels during cellular aging. In addition, we observed similar changes in the abundance of several amino acids in the metabolome of DMC-treated and GATA/Gln3 depleted cells. Here, we examine current data on the involvement of GATA TFs in the regulation of autophagy and longevity in different organisms and explore if GATA TFs might be suitable targets for anti-aging interventions. application/pdf https://folia.unifr.ch/global/documents/307885 https://folia.unifr.ch/documents/307885/files/den_tgt.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.15698/mic2019.05.676 info:eu-repo/semantics/openAccess License undefined Microbial Cell. - 2019, vol. 6, no. 5, p. 212–216 info:eu-repo/classification/udc/57 Targeting GATA transcription factors – a novel strategy for anti-aging interventions? http://purl.org/coar/resource_type/c_6501