<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Savić, Nada D.</dc:creator>
  <dc:creator>Vojnovic, Sandra</dc:creator>
  <dc:creator>Glišić, Biljana Đ.</dc:creator>
  <dc:creator>Crochet, Aurélien</dc:creator>
  <dc:creator>Pavic, Aleksandar</dc:creator>
  <dc:creator>Janjić, Goran V.</dc:creator>
  <dc:creator>Pekmezović, Marina</dc:creator>
  <dc:creator>Opsenica, Igor M.</dc:creator>
  <dc:creator>Fromm, Katharina M.</dc:creator>
  <dc:creator>Nikodinovic-Runic, Jasmina</dc:creator>
  <dc:creator>Djuran, Miloš I.</dc:creator>
  <dc:date>2018-08-05</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Mononuclear silver(I) complexes with 1,7-phenanthroline (1,7-phen), [Ag(NO3-O,O′)  (1,7-phen-N7)2] (1) and [Ag(1,7-phen-N7)2]X, X = ClO4− (2), CF3SO3− (3), BF4− (4)  and SbF6− (5) were synthesized and structurally characterized by NMR (1H and  13C), IR and UV–Vis spectroscopy and ESI mass spectrometry. The crystal structures  of 1, 3 and 4 were determined by single-crystal X-ray diffraction analysis. In all these  complexes, 1,7-phen coordinates to the Ag(I) ion in a monodentate fashion via the  less sterically hindered N7 nitrogen atom. The investigation of the solution stability of  1–5 in DMSO revealed that they are sufficiently stable in this solvent at room  temperature. Complexes 1–5 showed selectivity towards Candida spp. in comparison  to bacteria, effectively inhibiting the growth of four different Candida species with  minimal inhibitory concentrations (MIC) between 1.2 and 11.3 μM. Based on the  lowest MIC values and the lowest cytotoxicity against healthy human fibroblasts with  selectivity index of more than 30, the antifungal potential was examined in detail for  the complex 1. It had the ability to attenuate C. albicans virulence and to reduce  epithelial cell damage in the cell infection model. Induction of reactive oxygen species  (ROS) response has been detected in C. albicans, with fungal DNA being one of the  possible target biomolecules. The toxicity profile of 1 in the zebrafish model (Danio  rerio) revealed improved safety and activity in comparison to that of clinically utilized  silver(I) sulfadiazine.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/307351</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/307351/files/fro_msc.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/307351/files/fro_msc_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2018.07.049</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>European Journal of Medicinal Chemistry. - 2018, vol. 156, p. 760–773</dc:source>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Mononuclear silver(I) complexes with 1,7-phenanthroline as potent inhibitors of Candida growth</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>