<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Lannes, Nils</dc:creator>
  <dc:creator>Eppler, Elisabeth</dc:creator>
  <dc:creator>Etemad, Samar</dc:creator>
  <dc:creator>Yotovski, Peter</dc:creator>
  <dc:creator>Filgueira, Luis</dc:creator>
  <dc:date>2017-12-11</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Microglia cells are the unique residential macrophages of the central nervous system  (CNS). They have a special origin, as they derive from the embryonic yolk sac and  enter the developing CNS at a very early stage. They play an important role during  CNS development and adult homeostasis. They have a major contribution to adult  neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of  neurodegenerative diseases and contribute to aging. They play an important role in  sustaining and breaking the blood-brain barrier. As innate immune cells, they  contribute substantially to the immune response against infectious agents affecting the  CNS. They play also a major role in the growth of tumours of the CNS. Microglia are  consequently the key cell population linking the nervous and the immune system. This  review covers all different aspects of microglia biology and pathology in a  comprehensive way.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/307303</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/307303/files/fil_mcs.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.23106</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Oncotarget. - 2017, vol. 8, no. 69, p. 114393–114413</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Microglia</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Neuroinflammation</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Neurodegeneration</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Virus infection</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Brain cancer</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>