<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Messanga, Robert Ebeh</dc:creator>
  <dc:creator>Ngono Bikobo, Dominique Serge</dc:creator>
  <dc:creator>Zintchem, Auguste Abouem A.</dc:creator>
  <dc:creator>Mbabi Nyemeck II, Norbert</dc:creator>
  <dc:creator>Moni Ndedi, Esther Del Florence</dc:creator>
  <dc:creator>Betote Diboué, Patrick Hervé</dc:creator>
  <dc:creator>Nyegue, Maximilienne Ascension</dc:creator>
  <dc:creator>Atchadé, Alex de Théodore</dc:creator>
  <dc:creator>Pegnyemb, Dieudonné Emmanuel</dc:creator>
  <dc:creator>Bochet, Christian G.</dc:creator>
  <dc:creator>Koert, Ulrich</dc:creator>
  <dc:date>2018-08-18</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond)  (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside  derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2),  sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine  (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4  and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most  active (MIC = 7.8125 and 31.25 μg/mL) towards the Isoniazid resistant strain of  Mycobacterium tuberculosis AC45. Their structures and relative stereochemistry were  elucidated by spectroscopic methods.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/307237</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/307237/files/boc_rna.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/307237/files/boc_rna_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1080/14786419.2017.1356832</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Natural Product Research. - 2018, vol. 32, no. 16, p. 1971-1976</dc:source>
  <dc:subject>info:eu-repo/classification/udc/54</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae)</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>