Rehrauer, Hubert Wu, Licun Blum, Walter Pecze, László Henzi, Thomas Serre-Beinier, Véronique Aquino, Catherine Vrugt, Bart Perrot, Marc de Schwaller, Beat Felley-Bosco, Emanuela 2018-03-05 Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples. Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naïve mice supporting the role of the environment in tumor progression. application/pdf https://folia.unifr.ch/global/documents/306750 https://folia.unifr.ch/documents/306750/files/sch_hod.pdf https://folia.unifr.ch/documents/306750/files/sch_hod_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41388-018-0153-z info:eu-repo/semantics/openAccess License undefined Oncogene. - 2018, vol. 37, no. 20, p. 2645–2659 info:eu-repo/classification/udc/57 How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations http://purl.org/coar/resource_type/c_6501