Neuhaus, Frederik Mueller, Dennis Tanasescu, Radu Balog, Sandor Takashi Ishikawa Brezesinski, Gerald Zumbuehl, Andreas 2018-03-13 Nanomedicine suffers from low drug delivery efficiencies. Mechanoresponsive vesicles could provide an alternative way to release active compounds triggered by the basic physics of the human body. 1,3-Diamidophospholipids with C16 tails proved to be an effective building block for mechanoresponsive vesicles, but their low main phase transition temperature prevents an effective application in humans. As the main phase transition temperature of a membrane depends on the fatty acyl chain length, we synthesized a C17 homologue of a 1,3-diamidophospholipid: Rad-PC-Rad. The elevated main phase transition temperature of Rad-PC-Rad allows mechanoresponsive drug delivery at body temperature. Herein, we report the biophysical properties of Rad-PC-Rad monolayer and bilayer membranes. Rad-PC- Rad is an ideal candidate for advancing the concept of physically triggered drug release. application/pdf https://folia.unifr.ch/global/documents/306549 https://folia.unifr.ch/documents/306549/files/zum_sbc.pdf https://folia.unifr.ch/documents/306549/files/zum_sbc_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1021/acs.langmuir.7b04227 info:eu-repo/semantics/openAccess License undefined Langmuir. - 2018, vol. 34, no. 10, p. 3215–3220 info:eu-repo/classification/udc/54 Synthesis and biophysical characterization of an odd-numbered 1,3-diamidophospholipid http://purl.org/coar/resource_type/c_6501