Andreatta, Gabriele Kyriacou, Charalambos P. Flatt, Thomas Costa, Rodolfo 2018-02-01 In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. elegans and in several insects, but how neurosensory mechanisms act to relay environmental cues to the endocrine system in order to induce dormancy remains unclear. Here we examine this fundamental question by genetically manipulating aminergic neurotransmitter signaling in Drosophila melanogaster. We find that both serotonin and dopamine enhance adult ovarian dormancy, while the downregulation of their respective signaling pathways in endocrine cells or tissues (insulin producing cells, fat body, corpus allatum) reduces dormancy. In contrast, octopamine signaling antagonizes dormancy. Our findings enhance our understanding of the ability of organisms to cope with unfavorable environments and illuminate some of the relevant signaling pathways. application/pdf https://folia.unifr.ch/global/documents/306475 https://folia.unifr.ch/documents/306475/files/fla_asc.pdf https://folia.unifr.ch/documents/306475/files/fla_asc_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-20407-z info:eu-repo/semantics/openAccess License undefined Scientific Reports. - 2018, vol. 8, no. 1, p. 2030 info:eu-repo/classification/udc/57 Aminergic signaling controls ovarian dormancy in drosophila http://purl.org/coar/resource_type/c_6501