Neuhaus, Mireille Calabrese, Pasquale Annoni, Jean-Marie 2018 Background. Multiple sclerosis (MS) is frequently associated with cognitive and behavioural deficits. A growing number of studies suggest an impact of MS on decision-making abilities. The aim of this systematic review was to assess if (1) performance of MS patients in decision-making tasks was consistently different from controls and (2) whether this modification was associated with cognitive dysfunction and emotional alterations. Methods. The search was conducted on Pubmed/Medline database. 12 studies evaluating the difference between MS patients and healthy controls using validated decision-making tasks were included. Outcomes considered were quantitative (net scores) and qualitative measurements (deliberation time and learning from feedback). Results. Quantitative and qualitative decision-making impairment in MS was present in 64.7% of measurements. Patients were equally impaired in tasks for decision-making under risk and ambiguity. A correlation to other cognitive functions was present in 50% of cases, with the highest associations in the domains of processing speed and attentional capacity. Conclusions. In MS patients, qualitative and quantitative modifications may be present in any kind of decision- making task and can appear independently of other cognitive measures. Since decision-making abilities have a significant impact on everyday life, this cognitive aspect has an influential importance in various MS-related treatment settings. application/pdf https://folia.unifr.ch/global/documents/306472 https://folia.unifr.ch/documents/306472/files/ann_dmm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1155/2018/7835952 info:eu-repo/semantics/openAccess License undefined Multiple Sclerosis International. - 2018, vol. 2018, p. 7835952 info:eu-repo/classification/udc/57 Decision-making in multiple sclerosis patients: a systematic review http://purl.org/coar/resource_type/c_6501