<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Jayol, Aurélie</dc:creator>
  <dc:creator>Nordmann, Patrice</dc:creator>
  <dc:creator>Brink, Adrian</dc:creator>
  <dc:creator>Villegas, Maria-Virginia</dc:creator>
  <dc:creator>Dubois, Véronique</dc:creator>
  <dc:creator>Poirel, Laurent</dc:creator>
  <dc:date>2017-01-11</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Mutations in crrAB genes encoding a two-component regulator involved in  modifications of lipopolysaccharide were searched for among a collection of colistin- resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing  carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins  compared with those in wild-type strains. Complementation assays with a wild-type  CrrB protein restored the susceptibility to colistin in all cases, confirming the  involvement of the identified substitutions in the resistance phenotype.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/306106</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/306106/files/nor_hlr.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01423-17</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Antimicrobial Agents and Chemotherapy. - 2017, vol. 61, no. 11, p. e01423-17</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">High-level resistance to colistin mediated by various mutations in the crrb gene among carbapenemase-producing klebsiella pneumoniae</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>