Bicker, Frank Vasic, Verica Horta, Guilherme Ortega, Felipe Nolte, Hendrik Kavyanifar, Atria Keller, Stefanie Stankovic, Nevenka Dudvarski Harter, Patrick N. Benedito, Rui Lutz, Beat Baüerle, Tobias Hartwig, Jens Baumgart, Jan Krüger, Marcus Radyushkin, Konstantin Alberi, Lavinia Berninger, Benedikt Schmidt, Mirko H. H. 2017-06-28 Adult neural stem cells reside in a specialized niche in the subventricular zone (SVZ). Throughout life they give rise to adult-born neurons in the olfactory bulb (OB), thus contributing to neural plasticity and pattern discrimination. Here, we show that the neurovascular protein EGFL7 is secreted by endothelial cells and neural stem cells (NSCs) of the SVZ to shape the vascular stem-cell niche. Loss of EGFL7 causes an accumulation of activated NSCs, which display enhanced activity and re-entry into the cell cycle. EGFL7 pushes activated NSCs towards quiescence and neuronal progeny towards differentiation. This is achieved by promoting Dll4-induced Notch signalling at the blood vessel-stem cell interface. Fewer inhibitory neurons form in the OB of EGFL7-knockout mice, which increases the absolute signal conducted from the mitral cell layer of the OB but decreases neuronal network synchronicity. Consequently, EGFL7-knockout mice display severe physiological defects in olfactory behaviour and perception. application/pdf https://folia.unifr.ch/global/documents/305878 https://folia.unifr.ch/documents/305878/files/alb_ngr.pdf eng https://www.nature.com/articles/ncomms15922#supplementary-information info:eu-repo/semantics/altIdentifier/doi/10.1038/ncomms15922 info:eu-repo/semantics/openAccess License undefined Nature Communications. - 2017, vol. 8, p. ncomms15922 info:eu-repo/classification/udc/57 Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception http://purl.org/coar/resource_type/c_6501