Jain, Manish Zellweger, Matthieu Wagnières, Georges Bergh, Hubert van den Cook, Stéphane Giraud, Marie-Noëlle 2017-04-01 Acute coronary syndrome is a life-threatening condition of utmost clinical importance, which, despite recent progress in the field, is still associated with high morbidity and mortality. Acute coronary syndrome results from a rupture or erosion of vulnerable atherosclerotic plaque with secondary platelet activation and thrombus formation, which leads to partial or complete luminal obstruction of a coronary artery. During the last decade, scientific evidence demonstrated that when an acute coronary event occurs, several nonculprit plaques are in a “vulnerable” state. Among the promising approaches, several investigations provided evidence of photodynamic therapy (PDT)-induced stabilization and regression of atherosclerotic plaque. Significant development of PDT strategies improved its therapeutic outcome. This review addresses PDT's pertinence and major problems/challenges toward its translation to a clinical reality. application/pdf https://folia.unifr.ch/global/documents/305624 https://folia.unifr.ch/documents/305624/files/gir_ptt.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1111/1755-5922.12238 info:eu-repo/semantics/openAccess License undefined Cardiovascular Therapeutics. - 2017, vol. 35, no. 2, p. e12238 Atherosclerosis Laser Photodynamic therapy Photosensitizers Restenosis Theranostic info:eu-repo/classification/udc/57 Photodynamic therapy for the treatment of atherosclerotic plaque: Lost in translation? http://purl.org/coar/resource_type/c_6501