Collet, Carlos Asano, Taku Miyazaki, Yosuke Tenekecioglu, Erhan Katagiri, Yuki Sotomi, Yohei Cavalcante, Rafael Winter, Robbert J. de Kimura, Takeshi Gao, Runlin Puricel, Serban Cook, Stéphane Capodanno, Davide Onuma, Yoshinobu Serruys, Patrick W. 2017 To compare the long-term safety and efficacy of bioresorbable vascular scaffold (BVS) with everolimus-eluting stent (EES) after percutaneous coronary interventions.Methods and Results: A systematic review and meta-analysis of randomized clinical trials comparing clinical outcomes of patients treated with BVS and EES with at least 24 months follow-up was performed. Adjusted random-effect model by the Knapp–Hartung method was used to compute odds ratios (OR) and 95% confidence intervals (CI). The primary safety outcome of interest was the risk of definite/probable device thrombosis (DT). The primary efficacy outcome of interest was the risk of target lesion failure (TLF). Five randomized clinical trials (n = 1730) were included. Patients treated with Absorb BVS had a higher risk of definite/probable DT compared with patients treated with EES (OR 2.93, 95%CI 1.37–6.26, P = 0.01). Very late DT (VLDT) occurred in 13 patients [12/996 (1.4%, 95%CI: 0.08–2.5) Absorb BVS vs. 1/701 (0.5%, 95%CI: 0.2–1.6) EES; OR 3.04; 95%CI 1.2–7.68, P = 0.03], 92% of the VLDT in the BVS group occurred in the absence of dual antiplatelet therapy (DAPT). Patients treated with Absorb BVS had a trend towards higher risk of TLF (OR 1.48, 95%CI 0.90–2.42, P = 0.09), driven by a higher risk of target vessel myocardial infarction and ischaemia-driven target lesion revascularization. No difference was found in the risk of cardiac death.Conclusion: Compared with EES, the use of Absorb BVS was associated with a higher rate of DT and a trend towards higher risk of TLF. VLDT occurred in 1.4% of the patients, the majority of these events occurred in the absence of DAPT. application/pdf https://folia.unifr.ch/global/documents/305617 https://folia.unifr.ch/documents/305617/files/coo_lte.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1093/eurheartj/ehx155 info:eu-repo/semantics/openAccess License undefined European Heart Journal. - 2017, vol. 38, no. 33, p. 2559-2566 info:eu-repo/classification/udc/616 Late thrombotic events after bioresorbable scaffold implantation: a systematic review and meta-analysis of randomized clinical trials http://purl.org/coar/resource_type/c_6501