<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Crippa, Federica</dc:creator>
  <dc:creator>Moore, Thomas L.</dc:creator>
  <dc:creator>Mortato, Mariangela</dc:creator>
  <dc:creator>Geers, Christoph</dc:creator>
  <dc:creator>Haeni, Laetitia</dc:creator>
  <dc:creator>Hirt, Ann M.</dc:creator>
  <dc:creator>Rothen-Rutishauser, Barbara</dc:creator>
  <dc:creator>Petri-Fink, Alke</dc:creator>
  <dc:date>2017-04-01</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Magnetic thermo-responsive hydrogels are a new class of materials that have recently  attracted interest in biomedicine due to their ability to change phase upon magnetic  stimulation. They have been used for drug release, magnetic hyperthermia treatment,  and can potentially be engineered as stimuli-responsive substrates for cell  mechanobiology. In this regard, we propose a series of magnetic thermo-responsive  nanocomposite substrates that undergo cyclical swelling and de-swelling phases when  actuated by an alternating magnetic field in aqueous environment. The synthetized  substrates are obtained with a facile and reproducible method from poly-N- isopropylacrylamide and superparamagnetic iron oxide nanoparticles. Their  conformation and the temperature-related, magnetic, and biological behaviors were  characterized via scanning electron microscopy, swelling ratio analysis, vibrating  sample magnetometry, alternating magnetic field stimulation and indirect viability  assays. The nanocomposites showed no cytotoxicity with fibroblast cells, and  exhibited swelling/de-swelling behavior near physiological temperatures (around 34  °C). Therefore these magnetic thermo-responsive hydrogels are promising materials  as stimuli-responsive substrates allowing the study of cell-behavior by changing the  hydrogel properties in situ.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/305445</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/305445/files/fin_dbt.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmmm.2016.11.023</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Journal of Magnetism and Magnetic Materials. - 2017, vol. 427, p. 212–219</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Magnetic hydrogels</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">Magnetic nanoparticles</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">Hyperthermia</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">Stimuli-responsive substrates</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">Mechanobiology</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns6="xml" ns6:lang="en">Dynamic and biocompatible thermo-responsive magnetic hydrogels that respond to an alternating magnetic field</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>