<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Bahi, Amine</dc:creator>
  <dc:creator>Dreyer, Jean-Luc</dc:creator>
  <dc:date>2017-03-16</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Myelin Transcription Factor 1 (MyT1), a member of the Zinc Finger gene family, plays  a fundamental role in the nervous system. Recent research has suggested that this  transcription factor is associated with the pathophysiology of psychiatric disorders  including addiction, schizophrenia, and depression. However, the role of MyT1 in  anxiety- and ethanol-related behaviors is still unknown.Objectives: We evaluated the  effects of lentiviral-mediated overexpression of MyT1 in the dentate gyrus (DG) on  anxiety- and ethanol-related behaviors in rats.Methods: We used the elevated plus  maze (EPM) and the open field (OF) tests to assess anxiety-like behavior and a two- bottle choice procedure to measure the effects of MyT1 on ethanol intake and  preference.Results: MyT1 overexpression produced anxiolytic-like effects in the EPM  test and decreased the number of fecal boli in the OF test, without affecting locomotor  activity in both behavioral tests. Next, we demonstrated that ethanol intake and  preference were decreased in the MyT1-overexpressing rats with no effect on  saccharin and quinine, used to assess taste discrimination, and no effect on ethanol  clearance suggesting specific alterations in the rewarding effects of ethanol. Most  importantly, ectopic MyT1 overexpression increased both MyT1 and BDNF mRNA  levels in the DG. Using Pearson’s correlation, results showed a strong negative  relationship between MyT1 mRNA and anxiety parameters and ethanol consumption  and a positive correlation between MyT1 and BDNF mRNAs.Conclusion: Taken  together, MyT1 along with being a key component in anxiety may be a suitable  candidate in the search of the molecular underpinnings of alcoholism.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/305383</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/305383/files/dre_vmo.pdf</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/305383/files/dre_vmo_sm.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1007/s00213-017-4588-7</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Psychopharmacology. - 2017, p. 1–12</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Viral-mediated overexpression of the Myelin Transcription Factor 1 (MyT1) in the dentate gyrus attenuates anxiety- and ethanol-related behaviors in rats</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>