Kieffer, Nicolas Nordmann, Patrice Aires-de-Sousa, Marta Poirel, Laurent 2016-01-10 This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The blaOXA-181 (50/57) and blaNDM-1 (7/57) carbapenemase genes were identified. Notably, OXA-181-producing Escherichia coli isolates rarely coproduced extended-spectrum β-lactamases and consequently remained susceptible to broad-spectrum cephalosporins. The blaOXA-181 gene was always located on an IncX3 plasmid, while the blaNDM-1 gene was located on either IncFIA or IncA/C plasmids. The study identified a high prevalence of OXA-181 among hospitalized children in Angola. application/pdf https://folia.unifr.ch/global/documents/305347 https://folia.unifr.ch/documents/305347/files/nor_hpc.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01201-16 info:eu-repo/semantics/openAccess License undefined Antimicrobial Agents and Chemotherapy. - 2016, vol. 60, no. 10, p. 6189–6192 info:eu-repo/classification/udc/57 High prevalence of carbapenemase-producing enterobacteriaceae among hospitalized children in luanda, angola http://purl.org/coar/resource_type/c_6501