Chavan, Rohit Preitner, Nadia Okabe, Takashi Mansencal Strittmatter, Laureen Xu, Cheng Ripperger, Jürgen A. Pitteloud, Nelly Albrecht, Urs 2017-01-15 The circadian clock contributes to the timing of many body functions including metabolism and reproduction. The hepatokine fibroblast growth factor 21 (FGF21) is a critical metabolic regulator involved in modulation of fertility. Here we show that lack of the clock component REV-ERBα elevates FGF21 levels in liver and plasma. At the molecular level, REV-ERBα modulates the expression of FGF21 via the liver-specific hepatic nuclear factor 6 (HNF6). We conclude that REV-ERBα regulates metabolism and reproduction, at least in part, via regulation of Fgf21. application/pdf https://folia.unifr.ch/global/documents/305336 https://folia.unifr.ch/documents/305336/files/alb_rer.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1242/bio.021519 info:eu-repo/semantics/openAccess License undefined Biology Open. - 2017, vol. 6, no. 1, p. 1–7 info:eu-repo/classification/udc/57 REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6 http://purl.org/coar/resource_type/c_6501