Stalder, Etienne Zumbuehl, Andreas 2017-01-01 The direct injection of a drug into a joint can relieve osteoarthritic pain for a short period of time. The problem is that the drug will not stay at the allocated location. Therefore, a proof-of-concept in situ is designed forming hydrogel containing liposomes that are covalently linked to the hydrogel network. When the liposomes are filled with a cargo, the formed hydrogel is thus loaded with this cargo, too. Due to the link between the hydrogel and the liposomes, a compression or other mechanical force applied to the hydrogel will rupture the liposomes and release a small percentage of the cargo. Overall, a long-term intra-articular drug release is feasible. application/pdf https://folia.unifr.ch/global/documents/305179 https://folia.unifr.ch/documents/305179/files/zum_lcm_sm.pdf https://folia.unifr.ch/documents/305179/files/zum_lcm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1002/mame.201600549 info:eu-repo/semantics/openAccess License undefined Macromolecular Materials and Engineering. - 2017, vol. 302, no. 5, p. 1600549 arthritis hydrogels liposomes mechanoresponsive drug delivery on demand drug delivery info:eu-repo/classification/udc/57 Liposome‐containing mechanoresponsive hydrogels http://purl.org/coar/resource_type/c_6501