Anz, David Rapp, Moritz Eiber, Stephan Koelzer, Viktor H Thaler, Raffael Haubner, Sascha Knott, Max Nagel, Sarah Golic, Michaela Wiedemann, Gabriela M Bauernfeind, Franz Wurzenberger, Cornelia Hornung, Veit Scholz, Christoph Mayr, Doris Rothenfusser, Simon Endres, Stefan Bourquin, Carole 2015-10-02 The chemokine CCL22 is abundantly expressed in many types of cancer and is instrumental for intratumoral recruitment of regulatory T cells (Treg), an important subset of immunosuppressive and tumor-promoting lymphocytes. In this study, we offer evidence for a generalized strategy to blunt Treg activity that can limit immune escape and promote tumor rejection. Activation of innate immunity with Toll-like receptor (TLR) or RIG-I-like receptor (RLR) ligands prevented accumulation of Treg in tumors by blocking their immigration. Mechanistic investigations indicated Treg blockade was a consequence of reduced intratumoral CCL22 levels caused by type I interferon. Notably, stable expression of CCL22 abrogated the antitumor effects of treatment with RLR or TLR ligands. Taken together, our findings argue that type I interferon blocks the Treg-attracting chemokine CCL22 and thus helps limit the recruitment of Treg to tumors, a finding with implications for cancer immunotherapy. application/pdf https://folia.unifr.ch/global/documents/304750 https://folia.unifr.ch/documents/304750/files/bou_sic.pdf https://folia.unifr.ch/documents/304750/files/bou_sic_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1158/0008-5472.CAN-14-3499 info:eu-repo/semantics/openAccess License undefined Cancer Research. - 2015, vol. 75, no. 21, p. 4483-4493 info:eu-repo/classification/udc/57 Suppression of intratumoral CCL22 by type I interferon inhibits migration of regulatory T cells and blocks cancer progression http://purl.org/coar/resource_type/c_6501