<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Peirano, Gisele</dc:creator>
  <dc:creator>Bij, Akke K. van der</dc:creator>
  <dc:creator>Freeman, Joshua L.</dc:creator>
  <dc:creator>Poirel, Laurent</dc:creator>
  <dc:creator>Nordmann, Patrice</dc:creator>
  <dc:creator>Costello, Michael</dc:creator>
  <dc:creator>Tchesnokova, Veronika L.</dc:creator>
  <dc:creator>Pitout, Johann D. D.</dc:creator>
  <dc:date>2014-01-07</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">We designed a study to describe the characteristics of sequence type 131 (ST131) lineages, including the &lt;em&gt;H&lt;/em&gt;30-Rx sublineage, among a global collection of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates from 9 countries collected from 2000 to 2011. A total of 240 nonrepeat isolates from Canada, the United States, Brazil, the Netherlands, France, the United Arab Emirates (UAE), India, South Africa, and New Zealand were included. Established PCR, sequencing, and typing methods were used to define ST131 lineages, &lt;em&gt;H&lt;/em&gt;30 and &lt;em&gt;H&lt;/em&gt;30-Rx phylogenetic groups, &lt;em&gt;gyrA&lt;/em&gt; and &lt;em&gt;parC&lt;/em&gt; mutations, virotypes, and plasmid-mediated quinolone resistance determinants. The majority of the isolates produced CTX-M-15 with &lt;em&gt;aac(6′)-lb-cr&lt;/em&gt;, belonged to phylogenetic group B2, and were positive for the &lt;em&gt;H&lt;/em&gt;30 lineage with the &lt;em&gt;gyrA1AB&lt;/em&gt; and &lt;em&gt;parC1aAB&lt;/em&gt; mutations. ST131 showed 15 distinct pulsotypes; 43% of the isolates belonged to four pulsotypes, with a global distribution. Seventy-five percent of the ST131 isolates belonged to &lt;em&gt;H&lt;/em&gt;30-Rx; this sublineage was present in all the countries and was associated with multidrug resistance, &lt;em&gt;bla&lt;/em&gt;&lt;sub&gt;CTX-M-15&lt;/sub&gt;, &lt;em&gt;aac(6′)-lb-cr&lt;/em&gt;, and virotypes A and C. The &lt;em&gt;H&lt;/em&gt;41 lineage was negative for the ST131 &lt;em&gt;pabB&lt;/em&gt; allele-specific PCR. The multidrug-resistant &lt;em&gt;H&lt;/em&gt;30-Rx sublineage poses an important public health threat due to its global distribution, association with virotype C, and high prevalence among ST131 isolates that produce CTX-M-15.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/303638</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/303638/files/nor_cec.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.02428-14</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>Antimicrobial Agents and Chemotherapy. - 2014, vol. 58, no. 7, p. 3762–3767</dc:source>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns1="xml" ns1:lang="en">Characteristics of Escherichia coli sequence type 131 isolates that produce extended-spectrum β-lactamases: global distribution of the H30-Rx sublineage</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>