Guex, Anne Géraldine Frobert, A. Valentin, Jeremy Fortunato, G. Hegemann, D. Cook, Stéphane Carrel, Thierry P. Tevaearai, H.T. Giraud, Marie-Noëlle 2014-02-14 Cardiac tissue engineering approaches can deliver large numbers of cells to the damaged myocardium and have thus increasingly been considered as a possible curative treatment to counteract the high prevalence of progressive heart failure after myocardial infarction (MI). Optimal scaffold architecture and mechanical and chemical properties, as well as immune- and bio-compatibility, need to be addressed. We demonstrated that radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibres provide a suitable matrix for bone-marrow-derived mesenchymal stem cell (MSC) cardiac implantation. Using a rat model of chronic MI, we showed that MSC-seeded plasma-coated PCL grafts stabilized cardiac function and attenuated dilatation. Significant relative decreases of 13% of the ejection fraction (EF) and 15% of the fractional shortening (FS) were observed in sham treated animals; respective decreases of 20% and 25% were measured 4 weeks after acellular patch implantation, whereas a steadied function was observed 4 weeks after MSC-patch implantation (relative decreases of 6% for both EF and FS). application/pdf https://folia.unifr.ch/global/documents/303542 https://folia.unifr.ch/documents/303542/files/coo_pfe.pdf https://folia.unifr.ch/documents/303542/files/coo_pfe_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2014.01.006 info:eu-repo/semantics/openAccess License undefined Acta Biomaterialia. - 2014, vol. 10, no. 7, p. 2996–3006 Cardiac tissue engineering In vivo functional evaluation Electrospinning Plasma polymerization Echocardiography cell therapy info:eu-repo/classification/udc/61 Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization http://purl.org/coar/resource_type/c_6501