Marcelino, Helena Veyrat-Durebex, Christelle Summermatter, Serge Sarafian, Delphine Miles-Chan, Jennifer L. Arsenijevic, Denis Zani, Fabio Montani, Jean-Pierre Seydoux, Josiane Solinas, Giovanni Rohner-Jeanrenaud, Françoise Dulloo, Abdul G. 2012-09-06 Catch-up growth, a risk factor for type 2 diabetes, is characterized by hyperinsulinemia and accelerated body fat recovery. Using a rat model of semistarvation-refeeding that exhibits catch-up fat, we previously reported that during refeeding on a low-fat diet, glucose tolerance is normal but insulin-dependent glucose utilization is decreased in skeletal muscle and increased in adipose tissue, where de novo lipogenic capacity is concomitantly enhanced. Here we report that isocaloric refeeding on a high-fat (HF) diet blunts the enhanced in vivo insulin-dependent glucose utilization for de novo lipogenesis (DNL) in adipose tissue. These are shown to be early events of catch-up growth that are independent of hyperphagia and precede the development of overt adipocyte hypertrophy, adipose tissue inflammation, or defective insulin signaling. These results suggest a role for enhanced DNL as a glucose sink in regulating glycemia during catch-up growth, which is blunted by exposure to an HF diet, thereby contributing, together with skeletal muscle insulin resistance, to the development of glucose intolerance. Our findings are presented as an extension of the Randle cycle hypothesis, whereby the suppression of DNL constitutes a mechanism by which dietary lipids antagonize glucose utilization for storage as triglycerides in adipose tissue, thereby impairing glucose homeostasis during catch-up growth. application/pdf https://folia.unifr.ch/global/documents/302965 https://folia.unifr.ch/documents/302965/files/dull_rat.pdf https://folia.unifr.ch/documents/302965/files/dull_rat_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.2337/db12-0255 info:eu-repo/semantics/openAccess License undefined Diabetes. - 2013, vol. 62, no. 2, p. 362-372 info:eu-repo/classification/udc/57 A role for adipose tissue de novo lipogenesis in glucose homeostasis during catch-up growth : a randle cycle favoring fat storage http://purl.org/coar/resource_type/c_6501