Boyer, Frédéric Balado, Eric Piazza, Pier V. Dreyer, Jean-Luc Deroche-Gamonet, Véronique 2010-06-23 Except as a marker of cancer progression, gamma-synuclein (GSyn) had received little attention. Recent data showed however that GSyn modulates cocaine-induced locomotor effects, suggesting that it could also play a role in cocaine reinforcing effects. In the rat, siRNAs targeting GSyn expression were injected in the nucleus accumbens and cocaine reinforcing effects were evaluated by means of intravenous self-administration. A dose-response curve was followed by procedures of progressive ratio, extinction, cocaine- and cue-induced reinstatements. Decrease of GSyn expression increased self-administration over a large range of doses. This effect was associated with an increase in cocaine-induced reinstatement. The present data reveal that GSyn exert a specific negative control on cocaine-induced reinforcing and incentive effects. application/pdf https://folia.unifr.ch/global/documents/302054 https://folia.unifr.ch/documents/302054/files/dre_dgs.pdf https://folia.unifr.ch/documents/302054/files/dre_dgs_sm.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1369-1600.2010.00232.x info:eu-repo/semantics/openAccess License undefined Addiction Biology. - 2011, vol. 16, no. 1, p. 120–123 info:eu-repo/classification/udc/57 A decrease in gamma-synuclein expression within the nucleus accumbens increases cocaine intravenous self-administration in the rat http://purl.org/coar/resource_type/c_6501