Dimova, Ivanka Raicheva, Sashka Dimitrov, Rumen Doganov, Nikolai Toncheva, Draga 2009-06-20 Background: We selected 5 oncogenes with well-established roles in carcinogenesis – CCND1, ErbB1, ErbB2, c-mycand ZNF217– to investigate the coexistence of their copy imbalances in relation to the clinico-pathological characteristics of ovarian tumors. Materials and Methods: Fluorescence in situ hybridization for the 5 genes was applied to a preexisting tissue microarray. 38 ovarian tumors were successfully analyzed for copy number changes of the 5 genes. Results: At least one of these oncogenes was gained/amplified in 27 out of 38 tumors (71.1). We report the highest frequency of c-mycgenetic gain/amplification since it affected 42.1 of the ovarian tumors. We observed sequential involvement of copy number alterations of the other genes in the presence of c-mycdisruption. The incidence of copy number changes of the 5 oncogenes – both single and combinatorial – was higher in high-grade tumors. All double aberrations in the serous group comprised c-mycand ZNF217copy number increases. Conclusions: Our results revealed a combination between copy number increases of c-mycand ZNF217, associated with serous histology. The data from this combined analysis of the 5 oncogenes could be used as a basis in considering the combined approach in molecular-based therapy of ovarian cancer. application/pdf https://folia.unifr.ch/global/documents/301873 https://folia.unifr.ch/documents/301873/files/dim_ccn.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1159/000219368 info:eu-repo/semantics/openAccess License undefined Onkologie. - 2009, vol. 32, no. 7, p. 405-410 Ovarian cancer Oncogenes Genomic imbalances Fluorescence in situ hybridization info:eu-repo/classification/udc/57 Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers http://purl.org/coar/resource_type/c_6501