Reo, Emanuela Seum, Carole Spierer, Pierre Bontron, Séverine 2010-03-18 In <i>Drosophila</i>, SU(VAR)3-7 is an essential heterochromatin component. It is required for proper chromatin condensation, and changing its dose modifies position-effect variegation. Sumoylation is a post-translational modification shown to play a role in diverse biological processes. Here, we demonstrate that sumoylation is essential for proper heterochromatin function in <i>Drosophila</i> through modification of SU(VAR)3-7. Indeed, SU(VAR)3-7 is sumoylated at lysine K839; this modification is required for localization of SU(VAR)3-7 at pericentric heterochromatin, chromosome 4, and telomeres. In addition, sumoylation of SU(VAR)3-7 is a prerequisite for its ability to enhance position-effect variegation. Thus, these results show that the heterochromatic function of SU(VAR)3-7 depends on its own sumoylation, and unveil a role for sumoylation in <i>Drosophila</i> heterochromatin. application/pdf https://folia.unifr.ch/global/documents/301596 https://folia.unifr.ch/documents/301596/files/bon_sds.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1093/nar/gkq168 info:eu-repo/semantics/openAccess License undefined Nucleic Acids Research. - 2010, vol. 38, no. 13, p. 4254-4262 info:eu-repo/classification/udc/57 Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function http://purl.org/coar/resource_type/c_6501