<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Adriani, Walter</dc:creator>
  <dc:creator>Boyer, Frederic</dc:creator>
  <dc:creator>Leo, Damiana</dc:creator>
  <dc:creator>Canese, Rossella</dc:creator>
  <dc:creator>Podo, Franca</dc:creator>
  <dc:creator>Perrone-Capano, Carla</dc:creator>
  <dc:creator>Dreyer, Jean-Luc</dc:creator>
  <dc:creator>Laviola, Giovanni</dc:creator>
  <dc:date>2009-11-30</dc:date>
  <dc:description xmlns:ns0="xml" ns0:lang="en">Dysfunction of brain dopamine transporter (DAT) has been associated with sensation seeking and impulse-control disorders. We recently generated a new animal model by stereotaxical inoculation of lentiviral vectors, which allowed localized intra-accumbal delivery of modulators for DAT gene: GFP (green fluorescent protein) control, silencers (Sil), a regulatable enhancer (DAT+), or both (DAT+Sil). Wistar male rats were followed both for socio-emotional profiles and for propensity to seek risky, uncertain rewards. Elevated anxiety and affiliation towards an unfamiliar partner emerged in Sil rats. Interestingly, in DAT+Sil rats (and Sil rats to a lesser extent) levels of playful social interaction were markedly reduced compared to controls. These DAT+Sil rats displayed a marked ‘gambling-like’ profile (i.e. preference for a large/uncertain over a small/sure reward), which disappeared upon doxycycline-induced switch-off onto DAT enhancer, but consistently reappeared with doxycycline removal. MRI-guided ¹H-MRS (at 4.7 T) examinations in vivo (under anaesthesia) revealed changes in the bioenergetic metabolites (phosphocreatine and total creatine) for DAT+Sil rats, indicating a functional up-regulation of dorsal striatum (Str) and conversely a down-regulation of ventral striatum (i.e. nucleus accumbens, NAc). A combined profile of (1) enhanced proneness to gambling and (2) strong social withdrawal is thus associated with altered DAT-induced balance within forebrain dopamine systems. In fact, risk of developing a gambling-prone, social-avoidant psychopathology might be associated with (1) dominant semi-automatic strategies and/or habits, developed within Str circuits, and (2) reduced NAc function, with poorer feedback adjustment on decisions by aversive experiences.</dc:description>
  <dc:format>application/pdf</dc:format>
  <dc:identifier>https://folia.unifr.ch/global/documents/301425</dc:identifier>
  <dc:identifier>https://folia.unifr.ch/documents/301425/files/dreyer_swg.pdf</dc:identifier>
  <dc:language>eng</dc:language>
  <dc:relation>info:eu-repo/semantics/altIdentifier/doi/10.1017/S1461145709991210</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>License undefined</dc:rights>
  <dc:source>The International Journal of Neuropsychopharmacology. - 2010, vol. 13, no. 10, p. 1329-1342</dc:source>
  <dc:subject xmlns:ns1="xml" ns1:lang="en">Dopamine transporter</dc:subject>
  <dc:subject xmlns:ns2="xml" ns2:lang="en">impulse control</dc:subject>
  <dc:subject xmlns:ns3="xml" ns3:lang="en">in-vivo gene modulation</dc:subject>
  <dc:subject xmlns:ns4="xml" ns4:lang="en">light/dark emersion</dc:subject>
  <dc:subject xmlns:ns5="xml" ns5:lang="en">probabilistic delivery task</dc:subject>
  <dc:subject xmlns:ns6="xml" ns6:lang="en">social behaviour</dc:subject>
  <dc:subject>info:eu-repo/classification/udc/57</dc:subject>
  <dc:title xmlns:ns7="xml" ns7:lang="en">Social withdrawal and gambling-like profile after lentiviral manipulation of DAT expression in the rat accumbens</dc:title>
  <dc:type>http://purl.org/coar/resource_type/c_6501</dc:type>
</oai_dc:dc>