Prévot, Anne Julita, Monique Tung, David K. Mosig, Dolores 2009-01-24 Acute normocapnic hypoxemia can cause functional renal insufficiency by increasing renal vascular resistance (RVR), leading to renal hypoperfusion and decreased glomerular filtration rate (GFR). Insulin-like growth factor 1 (IGF-1) activity is low in fetuses and newborns and further decreases during hypoxia. IGF-1 administration to humans and adult animals induces pre- and postglomerular vasodilation, thereby increasing GFR and renal blood flow (RBF). A potential protective effect of IGF-1 on renal function was evaluated in newborn rabbits with hypoxemia-induced renal insufficiency. Renal function and hemodynamic parameters were assessed in 17 anesthetized and mechanically ventilated newborn rabbits. After hypoxemia stabilization, saline solution (time control) or IGF-1 (1 mg/kg) was given as an intravenous (i.v.) bolus, and renal function was determined for six 30-min periods. Normocapnic hypoxemia significantly increased RVR (+16%), leading to decreased GFR (−14%), RBF (−19%) and diuresis (−12%), with an increased filtration fraction (FF). Saline solution resulted in a worsening of parameters affected by hypoxemia. Contrarily, although mean blood pressure decreased slightly but significantly, IGF-1 prevented a further increase in RVR, with subsequent improvement of GFR, RBF and diuresis. FF indicated relative postglomerular vasodilation. Although hypoxemia- induced acute renal failure was not completely prevented, IGF-1 elicited efferent vasodilation, thereby precluding a further decline in renal function. application/pdf https://folia.unifr.ch/global/documents/301221 https://folia.unifr.ch/documents/301221/files/467_2008_Article_1098.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1007/s00467-008-1098-1 info:eu-repo/semantics/openAccess License undefined Pediatric Nephrology. - 2009, vol. 24, no. 5, p. 973-981 Hypoxemia Insulin-like growth factor-1 Kidney Newborn rabbit Survival info:eu-repo/classification/udc/57 Beneficial effect of insulin-like growth factor-1 on hypoxemic renal dysfunction in the newborn rabbit http://purl.org/coar/resource_type/c_6501