Bader, Rüdiger Colomb, Julien Pankratz, Bettina Schröck, Anne Stocker, Reinhard F. Pankratz, Michael J. 2007-04-13 The <i>hugin</i> gene of <i>Drosophila</i> encodes a neuropeptide with homology to mammalian neuromedin U. The <i>hugin</i>-expressing neurons are localized exclusively to the subesophageal ganglion of the central nervous system and modulate feeding behavior in response to nutrient signals. These neurons send neurites to the protocerebrum, the ventral nerve cord, the ring gland, and the pharynx and may interact with the gustatory sense organs. In this study, we have investigated the morphology of the <i>hugin</i> neurons at a single-cell level by using clonal analysis. We show that single cells project to only one of the four major targets. In addition, the neurites of the different <i>hugin</i> cells overlap in a specific brain region lateral to the foramen of the esophagus, which could be a new site of neuropeptide release for feeding regulation. Our study reveals novel complexity in the morphology of individual <i>hugin</i> neurons, which has functional implication for how they coordinate feeding behavior and growth. application/pdf https://folia.unifr.ch/global/documents/300442 https://folia.unifr.ch/documents/300442/files/stocker_gdn.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1002/cne.21342 info:eu-repo/semantics/openAccess License undefined The Journal of Comparative Neurology. - 2007, vol. 502, no. 5, p. 848 - 856 axon connectivity gustation neuropeptide interneuron morphology taste center info:eu-repo/classification/udc/57 Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila: Distinct classes of hugin-expressing neurons http://purl.org/coar/resource_type/c_6501