Cajochen, Christian Jud, Corinne Münch, Mirjam Kobialka, Szymon Wirz-Justice, Anna Albrecht, Urs 2006 We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders. application/pdf https://folia.unifr.ch/global/documents/299914 https://folia.unifr.ch/documents/299914/files/albrecht_eeb.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1460-9568.2006.04613.x info:eu-repo/semantics/openAccess License undefined European Journal of Neuroscience. - 2006, vol. 23, no. 4, p. 1082-1086 info:eu-repo/classification/udc/61 Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans http://purl.org/coar/resource_type/c_6501