Dobbelaere, Dirk AE Küenzi, Peter 2004-06-15 Theileria parasites infect and transform cells of the ruminant immune system. Continuous proliferation and survival of Theileria-transformed cells involves the well-orchestrated activation of several host-cell signalling pathways. Constitutive NF-κB (nuclear factor kappaB) activation is accomplished by recruiting the IKK (IκB kinase) complex, a central regulator of NF-κB pathways, to the surface of the transforming schizont, where it becomes permanently activated. Constitutive activation of the PI-3K–PKB [phosphoinositide 3-kinase–(Akt) protein kinase B] pathway is likely to be indirect and is essential for continuous proliferation. Theileria-transformed T cells express a range of anti-apoptotic proteins that can be expected to provide protection against apoptosis induced by death receptors, as well as cellular control mechanisms that are mobilised to eliminate cells that entered a cycle of uncontrolled proliferation. application/pdf https://folia.unifr.ch/global/documents/299553 https://folia.unifr.ch/documents/299553/files/1_kuenzi_stp.pdf eng info:eu-repo/semantics/altIdentifier/doi/10.1016/j.coi.2004.05.009 info:eu-repo/semantics/openAccess License undefined Current Opinion in Immunology. - 2004, vol. 16, no. 4, p. 524-530 info:eu-repo/classification/udc/57 The strategies of the Theileria parasite: a new twist in host–pathogen interactions http://purl.org/coar/resource_type/c_6501